Gene Variant Detail

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Gene RET
Variant G592_G607del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions RET G592_G607del results in the deletion of 16 amino acids in the extracellular domain of the Ret protein from amino acids 592 to 607 (UniProt.org). G592_G607del has been identified in the scientific literature (PMID: 35616103), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Apr 2024).
Associated Drug Resistance
Category Variants Paths

RET mutant RET G592_G607del

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Transcript NM_020975.6
gDNA chr10:g.43113570_43113617del48
cDNA c.1774_1821del48
Protein p.G592_G607del16
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020975.5 chr10:g.43113570_43113617del48 c.1774_1821del48 p.G592_G607del RefSeq GRCh38/hg38
NM_001406766.1 chr10:g.43114662_43114709del48 c.1774_1821del48 p.S592_Q607del16 RefSeq GRCh38/hg38
NM_001406764.1 chr10:g.43114504_43114551del48 c.1775_1822del48 p.R592_V607del16 RefSeq GRCh38/hg38
NM_001406768.1 chr10:g.43114638_43114685del48 c.1774_1821del48 p.A592_P607del16 RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43113570_43113617del48 c.1774_1821del48 p.G592_G607del16 RefSeq GRCh38/hg38
NM_001406763.1 chr10:g.43113570_43113617del48 c.1774_1821del48 p.G592_G607del16 RefSeq GRCh38/hg38
NM_001406783.1 chr10:g.43122015_43123716del1702 c.1774_1821del1702 p.V592_G607del16 RefSeq GRCh38/hg38
NM_001406790.1 chr10:g.43124902_43124949del48 c.1774_1821del48 p.C592_S607del16 RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43113570_43113617del48 c.1774_1821del48 p.G592_G607del16 RefSeq GRCh38/hg38
NM_001406776.1 chr10:g.43119638_43119685del48 c.1774_1821del48 p.N592_G607del16 RefSeq GRCh38/hg38
NM_001406785.1 chr10:g.43122007_43123708del1702 c.1775_1822del1702 p.Q592_T607del16 RefSeq GRCh38/hg38
NM_001406789.1 chr10:g.43124902_43124949del48 c.1774_1821del48 p.C592_S607del16 RefSeq GRCh38/hg38
NM_001406787.1 chr10:g.43123676_43123723del48 c.1775_1822del48 p.S592_P607del16 RefSeq GRCh38/hg38
NM_001406761.1 chr10:g.43114504_43114551del48 c.1775_1822del48 p.R592_V607del16 RefSeq GRCh38/hg38
NM_001406775.1 chr10:g.43119638_43119685del48 c.1774_1821del48 p.N592_G607del16 RefSeq GRCh38/hg38
NM_001406782.1 chr10:g.43120144_43120191del48 c.1774_1821del48 p.S592_V607del16 RefSeq GRCh38/hg38
NM_001406771.1 chr10:g.43116659_43116706del48 c.1774_1821del48 p.V592_T607del16 RefSeq GRCh38/hg38
NM_001406791.1 chr10:g.43126614_43126661del48 c.1774_1821del48 p.L592_D607del16 RefSeq GRCh38/hg38
NM_001406772.1 chr10:g.43116617_43116664del48 c.1774_1821del48 p.L592_V607del16 RefSeq GRCh38/hg38
NM_001406770.1 chr10:g.43114662_43114709del48 c.1774_1821del48 p.S592_Q607del16 RefSeq GRCh38/hg38
NM_001355216.2 chr10:g.43119674_43119721del48 c.1774_1821del48 p.L592_G607del16 RefSeq GRCh38/hg38
NM_001406778.1 chr10:g.43119638_43119685del48 c.1774_1821del48 p.N592_G607del16 RefSeq GRCh38/hg38
NM_001406773.1 chr10:g.43116659_43116706del48 c.1774_1821del48 p.V592_T607del16 RefSeq GRCh38/hg38
NM_001406786.1 chr10:g.43122015_43123716del1702 c.1774_1821del1702 p.V592_G607del16 RefSeq GRCh38/hg38
NM_001406793.1 chr10:g.43128207_43128254del48 c.1774_1821del48 p.V592_D607del16 RefSeq GRCh38/hg38
NM_001406779.1 chr10:g.43120144_43120191del48 c.1774_1821del48 p.S592_V607del16 RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43113570_43113617del48 c.1774_1821del48 p.G592_G607del RefSeq GRCh38/hg38
NM_001406769.1 chr10:g.43116617_43116664del48 c.1774_1821del48 p.L592_V607del16 RefSeq GRCh38/hg38
NM_001406780.1 chr10:g.43120144_43120191del48 c.1774_1821del48 p.S592_V607del16 RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43113570_43113617del48 c.1774_1821del48 p.G592_G607del16 RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43113570_43113617del48 c.1774_1821del48 p.G592_G607del16 RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43113570_43113617del48 c.1774_1821del48 p.G592_G607del16 RefSeq GRCh38/hg38
NM_001406788.1 chr10:g.43124902_43124949del48 c.1774_1821del48 p.C592_S607del16 RefSeq GRCh38/hg38
NM_001406784.1 chr10:g.43121979_43123680del1702 c.1774_1821del1702 p.S592_F607del16 RefSeq GRCh38/hg38
NM_001406774.1 chr10:g.43118388_43118435del48 c.1775_1822del48 p.S592_V607del16 RefSeq GRCh38/hg38
NM_001406767.1 chr10:g.43114662_43114709del48 c.1774_1821del48 p.S592_Q607del16 RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43113570_43113617del48 c.1774_1821del48 p.G592_G607del16 RefSeq GRCh38/hg38
NM_001406781.1 chr10:g.43120144_43120191del48 c.1774_1821del48 p.S592_V607del16 RefSeq GRCh38/hg38
NM_001406792.1 chr10:g.43128147_43128194del48 c.1774_1821del48 p.V592_Y607del16 RefSeq GRCh38/hg38
NM_001406765.1 chr10:g.43113570_43113617del48 c.1774_1821del48 p.G592_G607del16 RefSeq GRCh38/hg38
NM_001406777.1 chr10:g.43119638_43119685del48 c.1774_1821del48 p.N592_G607del16 RefSeq GRCh38/hg38
NM_001406762.1 chr10:g.43114504_43114551del48 c.1775_1822del48 p.R592_V607del16 RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References