Gene Variant Detail

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Gene RET
Variant I590_G607del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions RET I590_G607del results in the deletion of 18 amino acids in the extracellular domain of the Ret protein from amino acids 590 to 607 (UniProt.org). I590_G607del has been identified in the scientific literature (PMID: 35616103), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Apr 2024).
Associated Drug Resistance
Category Variants Paths

RET mutant RET I590_G607del

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Transcript NM_020975.6
gDNA chr10:g.43113565_43113618del54
cDNA c.1769_1822del54
Protein p.I590_G607del18
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406774.1 chr10:g.43118381_43118434del54 c.1768_1821del54 p.S590_V607del18 RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43113565_43113618del54 c.1769_1822del54 p.I590_G607del RefSeq GRCh38/hg38
NM_001406793.1 chr10:g.43128201_43128254del54 c.1768_1821del54 p.D590_D607del18 RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43113565_43113618del54 c.1769_1822del54 p.I590_G607del18 RefSeq GRCh38/hg38
NM_001406773.1 chr10:g.43116653_43116706del54 c.1768_1821del54 p.G590_T607del18 RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43113565_43113618del54 c.1769_1822del54 p.I590_G607del18 RefSeq GRCh38/hg38
NM_001406786.1 chr10:g.43122010_43123717del1708 c.1769_1822del1708 p.S590_G607del18 RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43113565_43113618del54 c.1769_1822del54 p.I590_G607del18 RefSeq GRCh38/hg38
NM_001406768.1 chr10:g.43114632_43114685del54 c.1768_1821del54 p.R590_P607del18 RefSeq GRCh38/hg38
NM_001406791.1 chr10:g.43126608_43126661del54 c.1768_1821del54 p.D590_D607del18 RefSeq GRCh38/hg38
NM_001406785.1 chr10:g.43122000_43123707del1708 c.1768_1821del1708 p.T590_T607del18 RefSeq GRCh38/hg38
NM_001406783.1 chr10:g.43122010_43123717del1708 c.1769_1822del1708 p.S590_G607del18 RefSeq GRCh38/hg38
NM_001406761.1 chr10:g.43114500_43114553del54 c.1771_1824del54 p.C591_L608del18 RefSeq GRCh38/hg38
NM_001406766.1 chr10:g.43114656_43114709del54 c.1768_1821del54 p.S590_Q607del18 RefSeq GRCh38/hg38
NM_001406770.1 chr10:g.43114656_43114709del54 c.1768_1821del54 p.S590_Q607del18 RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43113565_43113618del54 c.1769_1822del54 p.I590_G607del18 RefSeq GRCh38/hg38
NM_001406778.1 chr10:g.43119632_43119685del54 c.1768_1821del54 p.S590_G607del18 RefSeq GRCh38/hg38
NM_001406784.1 chr10:g.43121973_43123680del1708 c.1768_1821del1708 p.I590_F607del18 RefSeq GRCh38/hg38
NM_001406779.1 chr10:g.43120142_43120195del54 c.1772_1825del54 p.I591_K608del18 RefSeq GRCh38/hg38
NM_001406769.1 chr10:g.43116614_43116667del54 c.1771_1824del54 p.N591_K608del18 RefSeq GRCh38/hg38
NM_001406775.1 chr10:g.43119632_43119685del54 c.1768_1821del54 p.S590_G607del18 RefSeq GRCh38/hg38
NM_001406777.1 chr10:g.43119632_43119685del54 c.1768_1821del54 p.S590_G607del18 RefSeq GRCh38/hg38
NM_001406772.1 chr10:g.43116614_43116667del54 c.1771_1824del54 p.N591_K608del18 RefSeq GRCh38/hg38
NM_001406788.1 chr10:g.43124896_43124949del54 c.1768_1821del54 p.L590_S607del18 RefSeq GRCh38/hg38
NM_001355216.2 chr10:g.43119668_43119721del54 c.1768_1821del54 p.R590_G607del18 RefSeq GRCh38/hg38
NM_001406781.1 chr10:g.43120142_43120195del54 c.1772_1825del54 p.I591_K608del18 RefSeq GRCh38/hg38
NM_001406789.1 chr10:g.43124896_43124949del54 c.1768_1821del54 p.L590_S607del18 RefSeq GRCh38/hg38
NM_001406792.1 chr10:g.43128141_43128194del54 c.1768_1821del54 p.S590_Y607del18 RefSeq GRCh38/hg38
NM_001406762.1 chr10:g.43114500_43114553del54 c.1771_1824del54 p.C591_L608del18 RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43113565_43113618del54 c.1769_1822del54 p.I590_G607del18 RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43113565_43113618del54 c.1769_1822del54 p.I590_G607del18 RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43113565_43113618del54 c.1769_1822del54 p.I590_G607del RefSeq GRCh38/hg38
NM_001406763.1 chr10:g.43113565_43113618del54 c.1769_1822del54 p.I590_G607del18 RefSeq GRCh38/hg38
NM_001406776.1 chr10:g.43119632_43119685del54 c.1768_1821del54 p.S590_G607del18 RefSeq GRCh38/hg38
NM_001406771.1 chr10:g.43116653_43116706del54 c.1768_1821del54 p.G590_T607del18 RefSeq GRCh38/hg38
NM_001406780.1 chr10:g.43120142_43120195del54 c.1772_1825del54 p.I591_K608del18 RefSeq GRCh38/hg38
NM_001406782.1 chr10:g.43120142_43120195del54 c.1772_1825del54 p.I591_K608del18 RefSeq GRCh38/hg38
NM_001406790.1 chr10:g.43124896_43124949del54 c.1768_1821del54 p.L590_S607del18 RefSeq GRCh38/hg38
NM_001406765.1 chr10:g.43113565_43113618del54 c.1769_1822del54 p.I590_G607del18 RefSeq GRCh38/hg38
NM_001406787.1 chr10:g.43122015_43123722del1708 c.1768_1821del1708 p.V590_P607del18 RefSeq GRCh38/hg38
NM_001406764.1 chr10:g.43114500_43114553del54 c.1771_1824del54 p.C591_L608del18 RefSeq GRCh38/hg38
NM_001406767.1 chr10:g.43114656_43114709del54 c.1768_1821del54 p.S590_Q607del18 RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References