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Gene RET
Variant L629_D631delinsH
Impact List indel
Protein Effect unknown
Gene Variant Descriptions RET L629_D631delinsH results in a deletion of three amino acids in the extracellular domain of the Ret protein from amino acids 629 to 631, combined with the insertion of one histidine (H) at the same site (UniProt.org). L629_D631delinsH has been identified in the scientific literature (PMID: 35616103, PMID: 31605946), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Apr 2024).
Associated Drug Resistance
Category Variants Paths

RET mutant RET L629_D631delinsH

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Transcript NM_020975.6
gDNA chr10:g.43114486_43114491delTGTGCG
cDNA c.1886_1891delTGTGCG
Protein p.L629_D631delinsH
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020975.5 chr10:g.43114486_43114491delTGTGCG c.1886_1891delTGTGCG p.L629_D631delinsH RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43114486_43114491delTGTGCG c.1886_1891delTGTGCG p.L629_D631delinsH RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43114486_43114491delTGTGCG c.1886_1891delTGTGCG p.L629_D631delinsH RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43114486_43114491delTGTGCG c.1886_1891delTGTGCG p.L629_D631delinsH RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43114486_43114491delTGTGCG c.1886_1891delTGTGCG p.L629_D631delinsH RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43114486_43114491delTGTGCG c.1886_1891delTGTGCG p.L629_D631delinsH RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43114486_43114491delTGTGCG c.1886_1891delTGTGCG p.L629_D631delinsH RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43114486_43114491delTGTGCG c.1886_1891delTGTGCG p.L629_D631delinsH RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References