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Gene RET
Variant S649_V650insLLLL
Impact List insertion
Protein Effect unknown
Gene Variant Descriptions RET S649_V650insLLLL results in the insertion of four amino acids in the helical domain of the Ret protein between amino acids 649 and 650 (UniProt.org).). S649_V650insLLLL has been identified in the scientific literature (PMID: 35616103), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Apr 2024).
Associated Drug Resistance
Category Variants Paths

RET mutant RET S649_V650insLLLL

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Transcript NM_020975.6
gDNA chr10:g.43114547_43114548insCTTCTTCTTCTT
cDNA c.1947_1948insCTTCTTCTTCTT
Protein p.S649_V650insLLLL
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406744.1 chr10:g.43114547_43114548insCTTCTTCTTCTT c.1947_1948insCTTCTTCTTCTT p.S649_V650insLLLL RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43114547_43114548insCTTCTTCTTCTT c.1947_1948insCTTCTTCTTCTT p.S649_V650insLLLL RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43114547_43114548insCTTCTTCTTCTT c.1947_1948insCTTCTTCTTCTT p.S649_V650insLLLL RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43114547_43114548insCTTCTTCTTCTT c.1947_1948insCTTCTTCTTCTT p.S649_V650insLLLL RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43114547_43114548insCTTCTTCTTCTT c.1947_1948insCTTCTTCTTCTT p.S649_V650insLLLL RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43114547_43114548insCTTCTTCTTCTT c.1947_1948insCTTCTTCTTCTT p.S649_V650insLLLL RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43114547_43114548insCTTCTTCTTCTT c.1947_1948insCTTCTTCTTCTT p.S649_V650insLLLL RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43114547_43114548insCTTCTTCTTCTT c.1947_1948insCTTCTTCTTCTT p.S649_V650insLLLL RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References