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| Gene | RET |
| Variant | V899_E902del |
| Impact List | deletion |
| Protein Effect | unknown |
| Gene Variant Descriptions | RET V899_E902del results in the deletion of four amino acids in the protein kinase domain of the Ret protein from amino acids 899 to 902 (UniProt.org). V899_E902del has been identified in the scientific literature (PMID: 35616103, PMID: 35470851), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Sep 2025). |
| Associated Drug Resistance | |
| Category Variants Paths |
RET mutant RET V899_E902del |
| Transcript | NM_020975.6 |
| gDNA | chr10:g.43120169_43120180del12 |
| cDNA | c.2696_2707del12 |
| Protein | p.V899_E902del |
| Source Database | RefSeq |
| Genome Build | GRCh38/hg38 |
| Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
|---|---|---|---|---|---|
| NM_001406760.1 | chr10:g.43120169_43120180del12 | c.2696_2707del12 | p.V899_E902del | RefSeq | GRCh38/hg38 |
| NM_020630.5 | chr10:g.43120169_43120180del12 | c.2696_2707del12 | p.V899_E902del | RefSeq | GRCh38/hg38 |
| NM_020975.5 | chr10:g.43120169_43120180del12 | c.2696_2707del12 | p.V899_E902del | RefSeq | GRCh38/hg38 |
| NM_001406743.1 | chr10:g.43120169_43120180del12 | c.2696_2707del12 | p.V899_E902del | RefSeq | GRCh38/hg38 |
| NM_001406744.1 | chr10:g.43120169_43120180del12 | c.2696_2707del12 | p.V899_E902del | RefSeq | GRCh38/hg38 |
| NM_020975.6 | chr10:g.43120169_43120180del12 | c.2696_2707del12 | p.V899_E902del | RefSeq | GRCh38/hg38 |
| NM_020630.7 | chr10:g.43120169_43120180del12 | c.2696_2707del12 | p.V899_E902del | RefSeq | GRCh38/hg38 |
| NM_001406759.1 | chr10:g.43120169_43120180del12 | c.2696_2707del12 | p.V899_E902del | RefSeq | GRCh38/hg38 |
| Molecular Profile | Protein Effect | Treatment Approaches |
|---|---|---|
| RET V899_E902del | unknown |