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Gene RET
Variant V899_E902del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions RET V899_E902del results in the deletion of four amino acids in the protein kinase domain of the Ret protein from amino acids 899 to 902 (UniProt.org). V899_E902del has been identified in the scientific literature (PMID: 35616103), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Apr 2024).
Associated Drug Resistance
Category Variants Paths

RET mutant RET V899_E902del

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Transcript NM_020975.6
gDNA chr10:g.43120169_43120180del12
cDNA c.2696_2707del12
Protein p.V899_E902delVYEE
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406770.1 chr10:g.43124926_43124937del12 c.2695_2706del12 p.R899_F902delRPVF RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43120169_43120180del12 c.2696_2707del12 p.V899_E902delVYEE RefSeq GRCh38/hg38
NM_001406766.1 chr10:g.43124926_43124937del12 c.2695_2706del12 p.R899_F902delRPVF RefSeq GRCh38/hg38
NM_001406762.1 chr10:g.43123693_43123704del12 c.2695_2706del12 p.W899_V902delWEIV RefSeq GRCh38/hg38
NM_001406767.1 chr10:g.43124926_43124937del12 c.2695_2706del12 p.R899_F902delRPVF RefSeq GRCh38/hg38
NM_001406765.1 chr10:g.43123699_43123710del12 c.2695_2706del12 p.I899_L902delIVTL RefSeq GRCh38/hg38
NM_001406763.1 chr10:g.43123699_43123710del12 c.2695_2706del12 p.I899_L902delIVTL RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43120169_43120180del12 c.2696_2707del12 p.V899_E902del RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43120169_43120180del12 c.2696_2707del12 p.V899_E902delVYEE RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43120169_43120180del12 c.2696_2707del12 p.V899_E902delVYEE RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43120169_43120180del12 c.2696_2707del12 p.V899_E902del RefSeq GRCh38/hg38
NM_001406761.1 chr10:g.43123693_43123704del12 c.2695_2706del12 p.W899_V902delWEIV RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43120169_43120180del12 c.2696_2707del12 p.V899_E902delVYEE RefSeq GRCh38/hg38
NM_001406768.1 chr10:g.43124902_43124913del12 c.2695_2706del12 p.C899_Q902delCWKQ RefSeq GRCh38/hg38
NM_001406772.1 chr10:g.43126628_43126639del12 c.2697_2708del12 p.D899_S902delDGLS RefSeq GRCh38/hg38
NM_001406771.1 chr10:g.43126668_43126679del12 c.2695_2706del12 p.N899_L902delNAPL RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43120169_43120180del12 c.2696_2707del12 p.V899_E902delVYEE RefSeq GRCh38/hg38
NM_001406773.1 chr10:g.43126668_43126679del12 c.2695_2706del12 p.N899_L902delNAPL RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43120169_43120180del12 c.2696_2707del12 p.V899_E902delVYEE RefSeq GRCh38/hg38
NM_001406769.1 chr10:g.43126628_43126639del12 c.2697_2708del12 p.D899_S902delDGLS RefSeq GRCh38/hg38
NM_001406764.1 chr10:g.43123693_43123704del12 c.2695_2706del12 p.W899_V902delWEIV RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References