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Gene APC
Variant Q886*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions APC Q886* results in a premature truncation of the Apc protein at amino acid 886 of 2843 (UniProt.org). Q886* has not been characterized, however, due to the effects of other truncation mutations downstream of Q886 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
Associated Drug Resistance
Category Variants Paths

APC mutant APC inact mut APC Q886*

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Transcript NM_000038.6
gDNA chr5:g.112838250C>T
cDNA c.2656C>T
Protein p.Q886*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354895.1 chr5:g.112838250C>T c.2656C>T p.Q886* RefSeq GRCh38/hg38
NM_001127510 chr5:g.112838250C>T c.2656C>T p.Q886* RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.112838250C>T c.2656C>T p.Q886* RefSeq GRCh38/hg38
NM_000038 chr5:g.112838250C>T c.2656C>T p.Q886* RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.112838250C>T c.2656C>T p.Q886* RefSeq GRCh38/hg38
NM_000038.6 chr5:g.112838250C>T c.2656C>T p.Q886* RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.112838250C>T c.2656C>T p.Q886* RefSeq GRCh38/hg38
NM_000038.5 chr5:g.112838250C>T c.2656C>T p.Q886* RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.112838250C>T c.2656C>T p.Q886* RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
APC Q886* colorectal cancer predicted - resistant XAV939 Preclinical Actionable In a preclinical study, XAV939 treatment did not affect growth of mouse intestinal organoids expressing APC Q884* (corresponding to Q886* in human) in culture (PMID: 31337618). 31337618
APC Q886* colorectal cancer conflicting G007-LK Preclinical - Patient cell culture Actionable In a preclinical study, G007-LK inhibited viability of a patient-derived colorectal cancer cell line harboring APC Q886* in culture (PMID: 37968472). 37968472
APC Q886* colorectal cancer conflicting G007-LK Preclinical Actionable In a preclinical study, G007-LK treatment did not alter gene expression pattern or affect growth in mouse intestinal organoids expressing APC Q884* (corresponding to Q886* in human) in culture (PMID: 31337618). 31337618
APC Q886* colorectal cancer predicted - resistant NVP-TNKS656 Preclinical Actionable In a preclinical study, NVP-TNKS656 treatment did not affect growth of mouse intestinal organoids expressing APC Q884* (corresponding to Q886* in human) in culture (PMID: 31337618). 31337618