Gene Variant Detail

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Gene RET
Variant V591_G607del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions RET V591_G607del results in the deletion of 17 amino acids in the extracellular domain of the Ret protein from amino acids 591 to 607 (UniProt.org). V591_G607del has been identified in the scientific literature (PMID: 36053791), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Apr 2024).
Associated Drug Resistance
Category Variants Paths

RET mutant RET V591_G607del

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Transcript NM_020975.6
gDNA chr10:g.43113567_43113617del51
cDNA c.1771_1821del51
Protein p.V591_G607del17
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406763.1 chr10:g.43113567_43113617del51 c.1771_1821del51 p.V591_G607del17 RefSeq GRCh38/hg38
NM_001406793.1 chr10:g.43128205_43128255del51 c.1772_1822del51 p.S591_D607del17 RefSeq GRCh38/hg38
NM_001406764.1 chr10:g.43114500_43114550del51 c.1771_1821del51 p.C591_V607del17 RefSeq GRCh38/hg38
NM_001406773.1 chr10:g.43116657_43116707del51 c.1772_1822del51 p.K591_T607del17 RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43113567_43113617del51 c.1771_1821del51 p.V591_G607del17 RefSeq GRCh38/hg38
NM_001406783.1 chr10:g.43122012_43123716del1705 c.1771_1821del1705 p.D591_G607del17 RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43113567_43113617del51 c.1771_1821del51 p.V591_G607del17 RefSeq GRCh38/hg38
NM_001406767.1 chr10:g.43114659_43114709del51 c.1771_1821del51 p.Y591_Q607del17 RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43113567_43113617del51 c.1771_1821del51 p.V591_G607del17 RefSeq GRCh38/hg38
NM_001406772.1 chr10:g.43116616_43116666del51 c.1773_1823del51 p.N591_V607del17 RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43113567_43113617del51 c.1771_1821del51 p.V591_G607del17 RefSeq GRCh38/hg38
NM_001406782.1 chr10:g.43120142_43120192del51 c.1772_1822del51 p.I591_V607del17 RefSeq GRCh38/hg38
NM_001406761.1 chr10:g.43114500_43114550del51 c.1771_1821del51 p.C591_V607del17 RefSeq GRCh38/hg38
NM_001355216.2 chr10:g.43119671_43119721del51 c.1771_1821del51 p.A591_G607del17 RefSeq GRCh38/hg38
NM_001406771.1 chr10:g.43116657_43116707del51 c.1772_1822del51 p.K591_T607del17 RefSeq GRCh38/hg38
NM_001406792.1 chr10:g.43128146_43128196del51 c.1773_1823del51 p.V592_P608del17 RefSeq GRCh38/hg38
NM_001406768.1 chr10:g.43114635_43114685del51 c.1771_1821del51 p.P591_P607del17 RefSeq GRCh38/hg38
NM_001406774.1 chr10:g.43118384_43118434del51 c.1771_1821del51 p.P591_V607del17 RefSeq GRCh38/hg38
NM_001406765.1 chr10:g.43113567_43113617del51 c.1771_1821del51 p.V591_G607del17 RefSeq GRCh38/hg38
NM_001406780.1 chr10:g.43120142_43120192del51 c.1772_1822del51 p.I591_V607del17 RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43113567_43113617del51 c.1771_1821del51 p.V591_G607del17 RefSeq GRCh38/hg38
NM_001406787.1 chr10:g.43123673_43123723del51 c.1772_1822del51 p.W591_P607del17 RefSeq GRCh38/hg38
NM_001406769.1 chr10:g.43116616_43116666del51 c.1773_1823del51 p.N591_V607del17 RefSeq GRCh38/hg38
NM_001406779.1 chr10:g.43120142_43120192del51 c.1772_1822del51 p.I591_V607del17 RefSeq GRCh38/hg38
NM_001406784.1 chr10:g.43121977_43123681del1705 c.1772_1822del1705 p.E591_F607del17 RefSeq GRCh38/hg38
NM_001406791.1 chr10:g.43126612_43126662del51 c.1772_1822del51 p.S591_D607del17 RefSeq GRCh38/hg38
NM_001406786.1 chr10:g.43122012_43123716del1705 c.1771_1821del1705 p.D591_G607del17 RefSeq GRCh38/hg38
NM_001406776.1 chr10:g.43119635_43119685del51 c.1771_1821del51 p.R591_G607del17 RefSeq GRCh38/hg38
NM_001406788.1 chr10:g.43124899_43124949del51 c.1771_1821del51 p.Q591_S607del17 RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43113567_43113617del51 c.1771_1821del51 p.V591_G607del17 RefSeq GRCh38/hg38
NM_001406785.1 chr10:g.43122003_43123707del1705 c.1771_1821del1705 p.T591_T607del17 RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43113567_43113617del51 c.1771_1821del51 p.V591_G607del RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43113567_43113617del51 c.1771_1821del51 p.V591_G607del17 RefSeq GRCh38/hg38
NM_001406778.1 chr10:g.43119635_43119685del51 c.1771_1821del51 p.R591_G607del17 RefSeq GRCh38/hg38
NM_001406777.1 chr10:g.43119635_43119685del51 c.1771_1821del51 p.R591_G607del17 RefSeq GRCh38/hg38
NM_001406789.1 chr10:g.43124899_43124949del51 c.1771_1821del51 p.Q591_S607del17 RefSeq GRCh38/hg38
NM_001406762.1 chr10:g.43114500_43114550del51 c.1771_1821del51 p.C591_V607del17 RefSeq GRCh38/hg38
NM_001406775.1 chr10:g.43119635_43119685del51 c.1771_1821del51 p.R591_G607del17 RefSeq GRCh38/hg38
NM_001406770.1 chr10:g.43114659_43114709del51 c.1771_1821del51 p.Y591_Q607del17 RefSeq GRCh38/hg38
NM_001406790.1 chr10:g.43124899_43124949del51 c.1771_1821del51 p.Q591_S607del17 RefSeq GRCh38/hg38
NM_001406781.1 chr10:g.43120142_43120192del51 c.1772_1822del51 p.I591_V607del17 RefSeq GRCh38/hg38
NM_001406766.1 chr10:g.43114659_43114709del51 c.1771_1821del51 p.Y591_Q607del17 RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References