CDKN2A G35_A36del
Gene Variant Detail

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Gene CDKN2A
Variant G35_A36del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions CDKN2A G35_A36del results in the deletion of two amino acids in ANK repeat 1 of the Cdkn2a protein from amino acids 35 to 36 (UniProt.org). G35_A36del has not been characterized in the scientific literature and therefore, its effect on Cdkn2a protein function is unknown (PubMed, Apr 2026).
Associated Drug Resistance
Category Variants Paths

CDKN2A mutant CDKN2A G35_A36del

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Transcript NM_000077.5
gDNA chr9:g.21974724_21974729delCCCGCC
cDNA c.103_108delGGGGCG
Protein p.G35_A36delGA
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_047422597.1 chr9:g.21971098_21971103delCCGGGC c.104_109delCCCGGG p.A35_R36delAR RefSeq GRCh38/hg38
NM_000077.5 chr9:g.21974724_21974729delCCCGCC c.103_108delGGGGCG p.G35_A36delGA RefSeq GRCh38/hg38
NM_001363763.2 chr9:g.21971098_21971103delCCGGGC c.104_109delCCCGGG p.A35_R36delAR RefSeq GRCh38/hg38
XM_011517675.3 chr9:g.21974724_21974729delCCCGCC c.103_108delGGGGCG p.G35_A36delGA RefSeq GRCh38/hg38
NM_058195.4 chr9:g.21994225_21994230delGCTGCC c.103_108delGCAGCG p.A35_A36delAA RefSeq GRCh38/hg38
NM_001195132.2 chr9:g.21974724_21974729delCCCGCC c.103_108delGGGGCG p.G35_A36delGA RefSeq GRCh38/hg38
XM_011517676.3 chr9:g.21974724_21974729delCCCGCC c.103_108delGGGGCG p.G35_A36delGA RefSeq GRCh38/hg38
XM_047422598.1 chr9:g.21971098_21971103delCCGGGC c.104_109delCCCGGG p.A35_R36delAR RefSeq GRCh38/hg38
NM_000077.4 chr9:g.21974724_21974729delCCCGCC c.103_108delGGGGCG p.G35_A36del RefSeq GRCh38/hg38
NM_058197.4 chr9:g.21974724_21974729delCCCGCC c.103_108delGGGGCG p.G35_A36delGA RefSeq GRCh38/hg38
XM_011517676.2 chr9:g.21974724_21974729delCCCGCC c.103_108delGGGGCG p.G35_A36delGA RefSeq GRCh38/hg38
NM_001195132.1 chr9:g.21974724_21974729delCCCGCC c.103_108delGGGGCG p.G35_A36delGA RefSeq GRCh38/hg38
NM_058197.5 chr9:g.21974724_21974729delCCCGCC c.103_108delGGGGCG p.G35_A36delGA RefSeq GRCh38/hg38
XM_011517675.2 chr9:g.21974724_21974729delCCCGCC c.103_108delGGGGCG p.G35_A36delGA RefSeq GRCh38/hg38
XM_047422596.1 chr9:g.21971098_21971103delCCGGGC c.104_109delCCCGGG p.A35_R36delAR RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CDKN2A mutant pancreatic cancer no benefit Palbociclib Phase II Actionable In a Phase II trial (TAPUR), patients with pancreatic cancer harboring a CDKN2A mutation or loss of CDKN2A (n=10) did not demonstrate an objective response or stable disease at 16 weeks when treated with single therapy, Ibrance (palbociclib), demonstrating a median progression-free survival of 7.2 weeks and an overall survival of 12.4 weeks (JCO Precision Oncology, Aug 14, 2019; NCT02693535). detail...
CDKN2A mutant biliary tract cancer no benefit Palbociclib Phase II Actionable In a Phase II trial (TAPUR), patients with biliary cancer harboring a CDKN2A mutation or loss of CDKN2A (n=10) did not demonstrate an objective response or stable disease at 16 weeks when treated with single therapy, Ibrance (palbociclib), demonstrating a median progression-free survival of 7.3 weeks and an overall survival of 11.1 weeks (JCO Precision Oncology, Aug 14, 2019; NCT02693535). detail...
CDKN2A mutant skin melanoma not applicable N/A Guideline Risk Factor Germline CDKN2A mutations or polymorphisms are associated with increased risk of developing single or multiple primary cutaneous melanomas (NCCN.org). detail...
CDKN2A mutant head and neck cancer sensitive Palbociclib Phase II Actionable In a Phase II trial (TAPUR), Ibrance (palbociclib) treatment led to a disease control rate (DCR) of 40% (11/28), objective response rate (ORR) of 4% (1/28, 1 partial response), median progression-free survival (mPFS) of 11 weeks and median overall survival (mOS) of 42 weeks in patients with heavily pretreated head and neck cancer harboring CDKN2A alterations, and a DCR of 13% (5/40), ORR of 5% (2/40), mPFS of 8 weeks, and mOS of 26 weeks in patients with advanced solid tumors (PMID: 39413339; NCT02693535). 39413339
CDKN2A mutant pancreatic cancer not applicable N/A Guideline Risk Factor Germline mutations in CDKN2A results in familial malignant melanoma syndrome, which is associated with increased risk of developing pancreatic cancer (NCCN.org). detail...