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Gene | BRAF |
Variant | A33T |
Impact List | missense |
Protein Effect | no effect - predicted |
Gene Variant Descriptions | BRAF A33T does not lie within any known functional domains of the Braf protein (UniProt.org). A33T results in Erk pathway activation similar to wild-type Braf in cultured cells (PMID: 31515458), and therefore, is predicted to have no effect on Braf protein function. |
Associated Drug Resistance | |
Category Variants Paths |
BRAF mutant BRAF A33T |
Transcript | NM_004333.6 |
gDNA | chr7:g.140924607C>T |
cDNA | c.97G>A |
Protein | p.A33T |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |