Gene Variant Detail

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Gene BRAF
Variant A33T
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions BRAF A33T does not lie within any known functional domains of the Braf protein (UniProt.org). A33T results in Erk pathway activation similar to wild-type Braf in cultured cells (PMID: 31515458), and therefore, is predicted to have no effect on Braf protein function.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF A33T

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Transcript NM_004333.6
gDNA chr7:g.140924607C>T
cDNA c.97G>A
Protein p.A33T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001378475.1 chr7:g.140924607C>T c.97G>A p.A33T RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140924607C>T c.97G>A p.A33T RefSeq GRCh38/hg38
NM_001378471.1 chr7:g.140924607C>T c.97G>A p.A33T RefSeq GRCh38/hg38
NM_001378470.1 chr7:g.140924607C>T c.97G>A p.A33T RefSeq GRCh38/hg38
XM_047420770.1 chr7:g.140800411C>T c.97G>A p.A33T RefSeq GRCh38/hg38
XM_017012558.1 chr7:g.140924607C>T c.97G>A p.A33T RefSeq GRCh38/hg38
XM_017012559.2 chr7:g.140924607C>T c.97G>A p.A33T RefSeq GRCh38/hg38
NM_001378469.1 chr7:g.140924607C>T c.97G>A p.A33T RefSeq GRCh38/hg38
XM_047420767.1 chr7:g.140924607C>T c.97G>A p.A33T RefSeq GRCh38/hg38
XM_017012559.1 chr7:g.140924607C>T c.97G>A p.A33T RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140924607C>T c.97G>A p.A33T RefSeq GRCh38/hg38
NM_001374244.1 chr7:g.140924607C>T c.97G>A p.A33T RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140924607C>T c.97G>A p.A33T RefSeq GRCh38/hg38
XM_047420768.1 chr7:g.140924607C>T c.97G>A p.A33T RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140924607C>T c.97G>A p.A33T RefSeq GRCh38/hg38
NM_001378467.1 chr7:g.140924607C>T c.97G>A p.A33T RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140924607C>T c.97G>A p.A33T RefSeq GRCh38/hg38
NM_001374258.1 chr7:g.140924607C>T c.97G>A p.A33T RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140924607C>T c.97G>A p.A33T RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140924607C>T c.97G>A p.A33T RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References