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BRAF M484_N486del - Gene Variant Detail

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Gene BRAF
Variant M484_N486del
Impact List deletion
Protein Effect gain of function - predicted
Gene Variant Descriptions BRAF M484_N486del results in the deletion of three amino acids within the alphaC-helix region in the protein kinase domain of the Braf protein (PMID: 26732095). M484_N486del has not been characterized, however, is predicted to lead to a gain of protein function due to other characterized BRAF deletions in the same region (PMID: 26732095).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF act mut BRAF M484_N486del

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Transcript NM_004333.6
gDNA chr7:g.140778050_140778058delATTCAACAT
cDNA c.1450_1458delATGTTGAAT
Protein p.M484_N486delMLN
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.