BRAF M484_N486del
Gene Variant Detail

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Gene BRAF
Variant M484_N486del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions BRAF M484_N486del results in the deletion of three amino acids within the protein kinase domain of the Braf protein (UniProt). M484_N486del has not been characterized in the scientific literature and therefore, its effect on Braf protein function is unknown (PubMed, Mar 2026).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF M484_N486del

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Transcript NM_004333.6
gDNA chr7:g.140778050_140778058delATTCAACAT
cDNA c.1450_1458delATGTTGAAT
Protein p.M484_N486delMLN
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_047420766.1 chr7:g.140778014_140778022delGAAGGCTTG c.1450_1458delCAAGCCTTC p.Q484_F486delQAF RefSeq GRCh38/hg38
NM_001374258.1 chr7:g.140781670_140781678delCGAGTCCCG c.1450_1458delCGGGACTCG p.R484_S486delRDS RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140778050_140778058delATTCAACAT c.1450_1458delATGTTGAAT p.M484_N486delMLN RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140778050_140778058delATTCAACAT c.1450_1458delATGTTGAAT p.M484_N486delMLN RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140778050_140778058delATTCAACAT c.1450_1458delATGTTGAAT p.M484_N486delMLN RefSeq GRCh38/hg38
NM_001378473.1 chr7:g.140776992_140777000delATACAAGCT c.1450_1458delAGCTTGTAT p.S484_Y486delSLY RefSeq GRCh38/hg38
XM_047420767.1 chr7:g.140781670_140781678delCGAGTCCCG c.1450_1458delCGGGACTCG p.R484_S486delRDS RefSeq GRCh38/hg38
NM_001378472.1 chr7:g.140776992_140777000delATACAAGCT c.1450_1458delAGCTTGTAT p.S484_Y486delSLY RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140778050_140778058delATTCAACAT c.1450_1458delATGTTGAAT p.M484_N486del RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140778050_140778058delATTCAACAT c.1450_1458delATGTTGAAT p.M484_N486delMLN RefSeq GRCh38/hg38
NM_001378467.1 chr7:g.140778059_140778067delTTTCACTGC c.1450_1458delGCAGTGAAA p.A484_K486delAVK RefSeq GRCh38/hg38
XM_017012559.2 chr7:g.140781670_140781678delCGAGTCCCG c.1450_1458delCGGGACTCG p.R484_S486delRDS RefSeq GRCh38/hg38
NM_001374244.1 chr7:g.140781670_140781678delCGAGTCCCG c.1450_1458delCGGGACTCG p.R484_S486delRDS RefSeq GRCh38/hg38
XM_047420768.1 chr7:g.140781670_140781678delCGAGTCCCG c.1450_1458delCGGGACTCG p.R484_S486delRDS RefSeq GRCh38/hg38
NM_001378471.1 chr7:g.140777037_140777045delTGGCTTTGT c.1450_1458delACAAAGCCA p.T484_P486delTKP RefSeq GRCh38/hg38
XM_047420770.1 chr7:g.140734726_140734734delAATTTTTGG c.1451_1459delCAAAAATTC p.P484_I486delPKI RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140778050_140778058delATTCAACAT c.1450_1458delATGTTGAAT p.M484_N486delMLN RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140778050_140778058delATTCAACAT c.1450_1458delATGTTGAAT p.M484_N486del RefSeq GRCh38/hg38
NM_001378470.1 chr7:g.140777046_140777054delGGAATAGCC c.1450_1458delGGCTATTCC p.G484_S486delGYS RefSeq GRCh38/hg38
NM_001378475.1 chr7:g.140754206_140754214delGTGGATGAT c.1451_1459delTCATCCACA p.I484_H486delIIH RefSeq GRCh38/hg38
NM_001378469.1 chr7:g.140777082_140777992del911 c.1450_1458del911 p.K485_R487delKTR RefSeq GRCh38/hg38

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Molecular Profile Protein Effect Treatment Approaches
BRAF M484_N486del unknown MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor