BRAF G466V
Gene Variant Detail

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Gene BRAF
Variant G466V
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions BRAF G466V lies within the protein kinase domain of the Braf protein (UniProt.org). G466V is a BRAF class 3 variant that results in impaired Braf kinase activity, but paradoxically activates MEK and ERK through transactivation of CRAF in cell culture (PMID: 22649091, PMID: 28783719), and in one of two cell lines, G466V decreased cell proliferation and cell viability as compared to wild-type Braf (PMID: 29533785).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF G466X BRAF G466V

BRAF mutant BRAF inact mut BRAF G466V

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Transcript NM_004333.6
gDNA chr7:g.140781611C>A
cDNA c.1397G>T
Protein p.G466V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001378474.1 chr7:g.140781611C>A c.1397G>T p.G466V RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140781611C>A c.1397G>T p.G466V RefSeq GRCh38/hg38
XM_005250045 chr7:g.140781611C>A c.1397G>T p.G466V RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140781611C>A c.1397G>T p.G466V RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140781611C>A c.1397G>T p.G466V RefSeq GRCh38/hg38
NM_001378473.1 chr7:g.140777053C>A c.1397G>T p.G466V RefSeq GRCh38/hg38
NM_001378472.1 chr7:g.140777053C>A c.1397G>T p.G466V RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140781611C>A c.1397G>T p.G466V RefSeq GRCh38/hg38
NM_001378471.1 chr7:g.140778000C>A c.1397G>T p.G466V RefSeq GRCh38/hg38
NM_004333 chr7:g.140781611C>A c.1397G>T p.G466V RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140781611C>A c.1397G>T p.G466V RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140781611C>A c.1397G>T p.G466V RefSeq GRCh38/hg38
XM_047420766.1 chr7:g.140778075C>A c.1397G>T p.G466V RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries