KEAP1 R272L
Gene Variant Detail

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Gene KEAP1
Variant R272L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions KEAP1 R272L lies within the BACK domain of the Keap1 protein (UniProt.org). R272L has been identified in sequencing studies (PMID: 31828882), but has not been biochemically characterized and therefore, its effect on Keap1 protein function is unknown (PubMed, Oct 2025).
Associated Drug Resistance
Category Variants Paths

KEAP1 mutant KEAP1 R272L

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Transcript NM_203500.2
gDNA chr19:g.10492087C>A
cDNA c.815G>T
Protein p.R272L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005260173.1 chr19:g.10492087C>A c.815G>T p.R272L RefSeq GRCh38/hg38
XM_005260174.1 chr19:g.10492087C>A c.815G>T p.R272L RefSeq GRCh38/hg38
NM_012289.4 chr19:g.10492087C>A c.815G>T p.R272L RefSeq GRCh38/hg38
NM_203500.1 chr19:g.10492087C>A c.815G>T p.R272L RefSeq GRCh38/hg38
XM_011528452.1 chr19:g.10492087C>A c.815G>T p.R272L RefSeq GRCh38/hg38
NM_203500.2 chr19:g.10492087C>A c.815G>T p.R272L RefSeq GRCh38/hg38
NM_012289.3 chr19:g.10492087C>A c.815G>T p.R272L RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
KEAP1 R272L unknown