Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Gene | RAD51C |
Variant | G113S |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | RAD51C G113S lies within the region required for Holliday junction resolution activity and the Rad51b, Rad51d, and Xrcc3-interacting region of the Rad51c protein (UniProt.org). G113S retains binding with Xrcc3 but demonstrates decreased interaction with Rad51b and Rad51d in a yeast assay (PMID: 36099300), but has not been fully biochemically characterized and therefore, its effect on Rad51c protein function is unknown. |
Associated Drug Resistance | |
Category Variants Paths |
RAD51C mutant RAD51C G113S |
Transcript | NM_058216.3 |
gDNA | chr17:g.58695122G>A |
cDNA | c.337G>A |
Protein | p.G113S |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
XM_006722002.4 | chr17:g.58695122G>A | c.337G>A | p.G113S | RefSeq | GRCh38/hg38 |
NM_002876.3 | chr17:g.58695122G>A | c.337G>A | p.G113S | RefSeq | GRCh38/hg38 |
NM_058216.3 | chr17:g.58695122G>A | c.337G>A | p.G113S | RefSeq | GRCh38/hg38 |
XM_006722002.5 | chr17:g.58695122G>A | c.337G>A | p.G113S | RefSeq | GRCh38/hg38 |
NM_002876.4 | chr17:g.58695122G>A | c.337G>A | p.G113S | RefSeq | GRCh38/hg38 |
XM_047436505.1 | chr17:g.58695122G>A | c.337G>A | p.G113S | RefSeq | GRCh38/hg38 |
XM_006722001.4 | chr17:g.58695122G>A | c.337G>A | p.G113S | RefSeq | GRCh38/hg38 |
XM_006722001.5 | chr17:g.58695122G>A | c.337G>A | p.G113S | RefSeq | GRCh38/hg38 |
NM_058216.2 | chr17:g.58695122G>A | c.337G>A | p.G113S | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|