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Therapy Name Saruparib
Synonyms
Therapy Description

AZD5305 inhibits PARP1, potentially inhibiting cell growth and inducing tumor regression (PMID: 35929986).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Saruparib AZD 5305|AZD-5305|AZD5305 PARP-1 Inhibitor 10 Saruparib (AZD5305) inhibits PARP1, potentially leading to tumor growth inhibition (PMID: 35929986).

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RAD51C del ovarian cancer sensitive Saruparib Preclinical - Cell culture Actionable In a preclinical study, Saruparib (AZD5305) inhibited colony formation in an ovarian cancer cell line with RAD51C deletion in culture (PMID: 35929986). 35929986

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05938270 Phase I Darolutamide Darolutamide + Saruparib Saruparib A Study to Investigate the Biological Effects of AZD5305, Darolutamide, and in Combination in Men With Newly Diagnosed Prostate Cancer. (ASCERTAIN) Recruiting USA | NLD | GBR | ESP | CAN | AUS 0
NCT04644068 Phase I Carboplatin + Paclitaxel + Saruparib Paclitaxel + Saruparib Carboplatin + Saruparib Saruparib Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies (PETRA) Recruiting USA | POL | ITA | HUN | GBR | ESP | CZE | CAN | AUS 5


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