FLT3 Y842D
Gene Variant Detail

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Gene FLT3
Variant Y842D
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FLT3 Y842D lies within the protein kinase domain of the Flt3 protein (UniProt.org). Y842D has been demonstrated to occur as a secondary resistance mutation in the context of FLT3 internal tandem duplication (FLT3-ITD) mutations (PMID: 19318574, PMID: 25487917), but has not been biochemically characterized and therefore, its effect on Flt3 protein function is unknown (PubMed, Oct 2025).
Associated Drug Resistance Y
Category Variants Paths

FLT3 mutant FLT3 exon20 FLT3 Y842D

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Transcript NM_004119.3
gDNA chr13:g.28018484A>C
cDNA c.2524T>G
Protein p.Y842D
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.2 chr13:g.28018484A>C c.2524T>G p.Y842D RefSeq GRCh38/hg38
NM_004119.3 chr13:g.28018484A>C c.2524T>G p.Y842D RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 Y842D acute myeloid leukemia predicted - sensitive Cytarabine + Idarubicin + Midostaurin Case Reports/Case Series Actionable In a clinical case study, Rydapt (midostaurin), Cytosar-U (cytarabine), and Idamycin (idarubicin) combination therapy resulted in complete morphological remission, allowing for subsequent allogeneic stem cell transplantation, in a patient with acute myeloid leukemia harboring FLT3 Y842D (PMID: 35549749). 35549749