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Profile Name | FLT3 Y842D |
Gene Variant Detail | |
Relevant Treatment Approaches |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
FLT3 Y842D | acute myeloid leukemia | predicted - sensitive | Cytarabine + Idarubicin + Midostaurin | Case Reports/Case Series | Actionable | In a clinical case study, Rydapt (midostaurin), Cytosar-U (cytarabine), and Idamycin (idarubicin) combination therapy resulted in complete morphological remission, allowing for subsequent allogeneic stem cell transplantation, in a patient with acute myeloid leukemia harboring FLT3 Y842D (PMID: 35549749). | 35549749 |