ABL1 D363G
Gene Variant Detail

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Gene ABL1
Variant D363G
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ABL1 D363G lies within the protein kinase domain of the Abl1 protein (UniProt.org). D363G has been associated with resistance to selected ABL1 inhibitors in the context of BCR-ABL1 (PMID: 37123466), but has not been biochemically characterized and therefore, its effect on Abl1 protein function is unknown (PubMed, Nov 2025).
Associated Drug Resistance Y
Category Variants Paths

ABL1 mutant ABL1 D363G

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Transcript NM_005157.6
gDNA chr9:g.130874870A>G
cDNA c.1088A>G
Protein p.D363G
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_005157.6 chr9:g.130874870A>G c.1088A>G p.D363G RefSeq GRCh38/hg38
NM_005157.5 chr9:g.130874870A>G c.1088A>G p.D363G RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
ABL1 D363G unknown