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Gene RAD51D
Variant L215Tfs*112
Impact List frameshift
Protein Effect unknown
Gene Variant Descriptions RAD51D L215Tfs*112 indicates a shift in the reading frame starting at amino acid 215 and terminating 112 residues downstream causing a premature truncation of the 328 amino acid Rad51d protein (UniProt.org). L215Tfs*112 has not been characterized in the scientific literature and therefore, its effect on Rad51d protein function is unknown (PubMed, Jun 2024).
Associated Drug Resistance
Category Variants Paths

RAD51D mutant RAD51D L215Tfs*112

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Transcript NM_002878.4
gDNA chr17:g.35103479dupT
cDNA c.642dupA
Protein p.L215Tfs*112
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002878.3 chr17:g.35103479dupT c.642dupA p.L215Tfs*112 RefSeq GRCh38/hg38
NM_002878.4 chr17:g.35103479dupT c.642dupA p.L215Tfs*112 RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RAD51D mutant ovarian cancer not applicable N/A Guideline Risk Factor Germline RAD51D mutations are associated with increased risk of developing ovarian cancer (NCCN.org). detail...
RAD51D mutant breast cancer not applicable N/A Guideline Risk Factor Germline RAD51D mutations are associated with increased risk of developing breast cancer (NCCN.org). detail...