RET G607C - Gene Variant Detail

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Gene RET
Variant G607C
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions RET G607C lies within the extracellular domain of the Ret protein (UniProt.org). G607C confers a gain of function to Ret as demonstrated by increased Erk phosphorylation and IL3-independent growth in culture (PMID: 36166639).
Associated Drug Resistance
Category Variants Paths

RET mutant RET act mut RET G607C

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Transcript NM_020975.6
gDNA chr10:g.43113615G>T
cDNA c.1819G>T
Protein p.G607C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406760.1 chr10:g.43113615G>T c.1819G>T p.G607C RefSeq GRCh38/hg38
NM_001406783.1 chr10:g.43123714_43123716delGGAinsTGT c.1819_1821delGGAinsTGT p.G607C RefSeq GRCh38/hg38
NM_001355216.2 chr10:g.43119719_43119721delGGGinsTGT c.1819_1821delGGGinsTGT p.G607C RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43113615G>T c.1819G>T p.G607C RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43113615G>T c.1819G>T p.G607C RefSeq GRCh38/hg38
NM_001406786.1 chr10:g.43123714_43123716delGGAinsTGT c.1819_1821delGGAinsTGT p.G607C RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43113615G>T c.1819G>T p.G607C RefSeq GRCh38/hg38
NM_001406775.1 chr10:g.43119683G>T c.1819G>T p.G607C RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43113615G>T c.1819G>T p.G607C RefSeq GRCh38/hg38
NM_001406778.1 chr10:g.43119683G>T c.1819G>T p.G607C RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43113615G>T c.1819G>T p.G607C RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43113615G>T c.1819G>T p.G607C RefSeq GRCh38/hg38
NM_001406763.1 chr10:g.43113615G>T c.1819G>T p.G607C RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43113615G>T c.1819G>T p.G607C RefSeq GRCh38/hg38
NM_001406776.1 chr10:g.43119683G>T c.1819G>T p.G607C RefSeq GRCh38/hg38
NM_001406777.1 chr10:g.43119683G>T c.1819G>T p.G607C RefSeq GRCh38/hg38
NM_001406765.1 chr10:g.43113615G>T c.1819G>T p.G607C RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Protein Effect Treatment Approaches
RET G607C gain of function RET Inhibitor