RET E768Q
Gene Variant Detail

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Gene RET
Variant E768Q
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET E768Q lies within the protein kinase domain of the Ret protein (UniProt.org). E768Q has been identified in the scientific literature (PMID: 37743366, PMID: 38754058), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Aug 2025).
Associated Drug Resistance
Category Variants Paths

RET mutant RET E768X RET E768Q

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Transcript NM_020975.6
gDNA chr10:g.43118390G>C
cDNA c.2302G>C
Protein p.E768Q
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020630.7 chr10:g.43118390G>C c.2302G>C p.E768Q RefSeq GRCh38/hg38
NM_001406774.1 chr10:g.43123696G>C c.2302G>C p.E768Q RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43118390G>C c.2302G>C p.E768Q RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43118390G>C c.2302G>C p.E768Q RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43118390G>C c.2302G>C p.E768Q RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43118390G>C c.2302G>C p.E768Q RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43118390G>C c.2302G>C p.E768Q RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References