RET G810N
Gene Variant Detail

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Gene RET
Variant G810N
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET G810N lies within the protein kinase domain of the Ret protein (UniProt.org). G810N has been associated with acquired resistance to RET inhibitors (PMID: 38127829), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Nov 2025).
Associated Drug Resistance Y
Category Variants Paths

RET mutant RET G810N

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Transcript NM_020975.6
gDNA chr10:g.43119566_43119567delGGinsAA
cDNA c.2428_2429delGGinsAA
Protein p.G810N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406743.1 chr10:g.43119566_43119567delGGinsAA c.2428_2429delGGinsAA p.G810N RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43119566_43119567delGGinsAA c.2428_2429delGGinsAA p.G810N RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43119566_43119567delGGinsAA c.2428_2429delGGinsAA p.G810N RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43119566_43119567delGGinsAA c.2428_2429delGGinsAA p.G810N RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43119566_43119567delGGinsAA c.2428_2429delGGinsAA p.G810N RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43119566_43119567delGGinsAA c.2428_2429delGGinsAA p.G810N RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
RET G810N unknown
RET G810N RET M918T