BRAF G474R
Gene Variant Detail

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Gene BRAF
Variant G474R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF G474R lies within the protein kinase domain of the Braf protein (UniProt.org). G474R results in a loss of downstream phosphorylation in culture, loss of kinase activity in in vitro analyses, and does not lead to downstream phosphorylation when co-expressed with Craf but does lead to TSH-induced proliferation in culture (PMID: 18697864), and therefore, its effect on Braf protein function is unknown.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF G474R

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Transcript NM_004333.6
gDNA chr7:g.140781588C>T
cDNA c.1420G>A
Protein p.G474R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001378474.1 chr7:g.140781588C>T c.1420G>A p.G474R RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140781588C>T c.1420G>A p.G474R RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140781588C>T c.1420G>A p.G474R RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140781588C>T c.1420G>A p.G474R RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140781588C>T c.1420G>A p.G474R RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
BRAF G474R unknown