TP53 Y220N
Gene Variant Detail

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Gene TP53
Variant Y220N
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 Y220N lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). Y220N is predicted to result in decreased Tp53 stability based on computer modeling (PMID: 31990523), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, May 2026).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon6 TP53 Y220N

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Transcript NM_000546.6
gDNA chr17:g.7674873A>T
cDNA c.658T>A
Protein p.Y220N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126113.3 chr17:g.7674873A>T c.658T>A p.Y220N RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7674873A>T c.658T>A p.Y220N RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7674873A>T c.658T>A p.Y220N RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7674873A>T c.658T>A p.Y220N RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7674873A>T c.658T>A p.Y220N RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7674873A>T c.658T>A p.Y220N RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7674873A>T c.658T>A p.Y220N RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7674873A>T c.658T>A p.Y220N RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7674873A>T c.658T>A p.Y220N RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 Y220N Advanced Solid Tumor no benefit Rezatapopt Preclinical - Cell culture Actionable In a preclinical study, Rezatapopt (PC14586) partially stabilized Tp53 protein and marginally inhibited proliferation, but did not inhibit viability and colony formation, and did not induce apoptosis in cells expressing TP53 Y220N in culture (PMID: 41748563). 41748563