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| Profile Name | TP53 Y220N |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| TP53 Y220N | Advanced Solid Tumor | no benefit | Rezatapopt | Preclinical - Cell culture | Actionable | In a preclinical study, Rezatapopt (PC14586) partially stabilized Tp53 protein and marginally inhibited proliferation, but did not inhibit viability and colony formation, and did not induce apoptosis in cells expressing TP53 Y220N in culture (PMID: 41748563). | 41748563 |