RAD51D K91Ifs*13
Gene Variant Detail

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Gene RAD51D
Variant K91Ifs*13
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions RAD51D K91Ifs*13 indicates a shift in the reading frame starting at amino acid 91 and terminating 13 residues downstream causing a premature truncation of the 328 amino acid Rad51d protein (UniProt.org). K91Ifs*13 results in similar levels of migration compared to wild-type Rad51d but fails to inhibit cell proliferation and results in increased sensitivity to PARP inhibitors in Rad51d knock-out cells in culture (PMID: 38905575), and therefore, is predicted to lead to a loss of Rad51d protein function.
Associated Drug Resistance
Category Variants Paths

RAD51D mutant RAD51D inact mut RAD51D K91fs RAD51D K91Ifs*13

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Transcript NM_002878.4
gDNA chr17:g.35107441_35107442dupAT
cDNA c.270_271dupTA
Protein p.K91Ifs*13
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002878.4 chr17:g.35107441_35107442dupAT c.270_271dupTA p.K91Ifs*13 RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RAD51D K91Ifs*13 ovarian cancer sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, Lynparza (olaparib) inhibited viability of ovarian cancer cell lines expressing RAD51D K91Ifs*13 in culture (PMID: 38905575). 38905575
RAD51D K91Ifs*13 ovarian cancer sensitive Niraparib Preclinical - Cell culture Actionable In a preclinical study, Zejula (niraparib) inhibited viability of ovarian cancer cell lines expressing RAD51D K91Ifs*13 in culture (PMID: 38905575). 38905575