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Gene BRAF
Variant G593V
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF G593V lies within the protein kinase domain of the Braf protein (UniProt.org). G593V is associated with EGFR inhibitor resistance in the context of an EGFR exon 19 deletion (PMID: 38838224), but has not been biochemically characterized and therefore, its effect on Braf protein function is unknown (PubMed, Jul 2024).
Associated Drug Resistance Y
Category Variants Paths

BRAF mutant BRAF G593V

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Transcript NM_004333.6
gDNA chr7:g.140753357C>A
cDNA c.1778G>T
Protein p.G593V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001378468.1 chr7:g.140753357C>A c.1778G>T p.G593V RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140753357C>A c.1778G>T p.G593V RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140753357C>A c.1778G>T p.G593V RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140753357C>A c.1778G>T p.G593V RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries