Gene Variant Detail

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Gene BRAF
Variant A366P
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF A366P does not lie within any known functional domains of the Braf protein (UniProt.org). A366P is associated with EGFR inhibitor resistance in the context of an EGFR exon 19 deletion (PMID: 38838224), but has not been biochemically characterized and therefore, its effect on Braf protein function is unknown (PubMed, Jul 2024).
Associated Drug Resistance Y
Category Variants Paths

BRAF mutant BRAF A366P

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Transcript NM_004333.6
gDNA chr7:g.140794352C>G
cDNA c.1096G>C
Protein p.A366P
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_047420768.1 chr7:g.140794352C>G c.1096G>C p.A366P RefSeq GRCh38/hg38
NM_001374258.1 chr7:g.140794352C>G c.1096G>C p.A366P RefSeq GRCh38/hg38
NM_001378471.1 chr7:g.140794352C>G c.1096G>C p.A366P RefSeq GRCh38/hg38
XM_017012559.2 chr7:g.140794352C>G c.1096G>C p.A366P RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140794352C>G c.1096G>C p.A366P RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140794352C>G c.1096G>C p.A366P RefSeq GRCh38/hg38
NM_001374244.1 chr7:g.140794352C>G c.1096G>C p.A366P RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140794352C>G c.1096G>C p.A366P RefSeq GRCh38/hg38
XM_047420767.1 chr7:g.140794352C>G c.1096G>C p.A366P RefSeq GRCh38/hg38
NM_001378469.1 chr7:g.140794352C>G c.1096G>C p.A366P RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140794352C>G c.1096G>C p.A366P RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140794352C>G c.1096G>C p.A366P RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References