BRAF G469L
Gene Variant Detail

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Gene BRAF
Variant G469L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF G469L lies within the protein kinase domain of the Braf protein (UniProt.org). G469L has been identified in the scientific literature (PMID: 24035431, PMID: 26301799, PMID: 26200454), but has not been biochemically characterized and therefore, its effect on Braf protein function is unknown (PubMed, Dec 2025).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF G469X BRAF G469L

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Transcript NM_004333.6
gDNA chr7:g.140781602_140781603delGGinsCT
cDNA c.1405_1406delGGinsCT
Protein p.G469L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_047420769.1 chr7:g.140781602_140781603delGGinsCT c.1405_1406delGGinsCT p.G469L RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140781602_140781603delGGinsCT c.1405_1406delGGinsCT p.G469L RefSeq GRCh38/hg38
NM_001378467.1 chr7:g.140781611_140781612delGGinsCT c.1405_1406delGGinsCT p.G469L RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140781602_140781603delGGinsCT c.1405_1406delGGinsCT p.G469L RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140781602_140781603delGGinsCT c.1405_1406delGGinsCT p.G469L RefSeq GRCh38/hg38
XM_005250045 chr7:g.140781602_140781603delCCinsAG c.1405_1406delGGinsCT p.G469L RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140781602_140781603delGGinsCT c.1405_1406delGGinsCT p.G469L RefSeq GRCh38/hg38
NM_004333 chr7:g.140781602_140781603delCCinsAG c.1405_1406delGGinsCT p.G469L RefSeq GRCh38/hg38
NM_001378470.1 chr7:g.140778000_140778001delGGinsCT c.1405_1406delGGinsCT p.G469L RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140781602_140781603delGGinsCT c.1405_1406delGGinsCT p.G469L RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140781602_140781603delGGinsCT c.1405_1406delGGinsCT p.G469L RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF G469L lung adenocarcinoma no benefit Vemurafenib Case Reports/Case Series Actionable In a clinical case study, a lung adenocarcinoma patient harboring BRAF G469L did not respond to Zelboraf (vemurafenib) therapy (PMID: 24035431). 24035431