Gene Variant Detail

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Gene BRAF
Variant G606A
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF G606A lies within the protein kinase domain of the Braf protein (UniProt.org). G606A has been identified in sequencing studies (PMID: 21825258), but has not been biochemically characterized and therefore, its effect on Braf protein function is unknown (PubMed, Aug 2024).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF G606A

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Transcript NM_004333.6
gDNA chr7:g.140753318C>G
cDNA c.1817G>C
Protein p.G606A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001378474.1 chr7:g.140753318C>G c.1817G>C p.G606A RefSeq GRCh38/hg38
NM_004333 chr7:g.140753318C>G c.1817G>C p.G606A RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140753318C>G c.1817G>C p.G606A RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140753318C>G c.1817G>C p.G606A RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140753318C>G c.1817G>C p.G606A RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140753318C>G c.1817G>C p.G606A RefSeq GRCh38/hg38
NM_001378471.1 chr7:g.140749351C>G c.1817G>C p.G606A RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140753318C>G c.1817G>C p.G606A RefSeq GRCh38/hg38
XM_005250045 chr7:g.140753318C>G c.1817G>C p.G606A RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References