MAP2K1 S194P
Gene Variant Detail

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Gene MAP2K1
Variant S194P
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions MAP2K1 S194P lies within the protein kinase domain of the Map2k1 protein (UniProt.org). S194P results in increased autophosphorylation, Erk1/2 phosphorylation, and proliferation in culture (PMID: 39313591), and has been demonstrated to confer resistance to Raf and Mek inhibitors in the context of BRAF V600E in culture (PMID: 39424923).
Associated Drug Resistance Y
Category Variants Paths

MAP2K1 mutant MAP2K1 act mut MAP2K1 S194P

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Transcript NM_002755.4
gDNA chr15:g.66481766T>C
cDNA c.580T>C
Protein p.S194P
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002755.4 chr15:g.66481766T>C c.580T>C p.S194P RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References