BRAF N581I
Gene Variant Detail

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Gene BRAF
Variant N581I
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF N581I lies within the protein kinase domain of the Braf protein (UniProt.org). N581I results in low Braf kinase activity and Ras-dependent activation of Erk signaling in cell culture (PMID: 28783719), however, also results in increased transformation ability compared to wild-type Braf in culture (PMID: 29533785), and therefore, its effect on Braf protein function is unknown.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF N581X BRAF N581I

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Transcript NM_004333.6
gDNA chr7:g.140753393T>A
cDNA c.1742A>T
Protein p.N581I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004333 chr7:g.140753393T>A c.1742A>T p.N581I RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140753393T>A c.1742A>T p.N581I RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140753393T>A c.1742A>T p.N581I RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140753393T>A c.1742A>T p.N581I RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140753393T>A c.1742A>T p.N581I RefSeq GRCh38/hg38
XM_005250045 chr7:g.140753393T>A c.1742A>T p.N581I RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140753393T>A c.1742A>T p.N581I RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140753393T>A c.1742A>T p.N581I RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries