Gene Variant Detail

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Gene BRAF
Variant R462K
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions BRAF R462K lies within the protein kinase domain of the Braf protein (UniProt.org). R462K has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Braf in culture (PMID: 29533785), and therefore, is predicted to have no effect on Braf protein function.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF R462X BRAF R462K

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Transcript NM_004333.6
gDNA chr7:g.140781623C>T
cDNA c.1385G>A
Protein p.R462K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004333 chr7:g.140781623C>T c.1385G>A p.R462K RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140781623C>T c.1385G>A p.R462K RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140781623C>T c.1385G>A p.R462K RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140781623C>T c.1385G>A p.R462K RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140781623C>T c.1385G>A p.R462K RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140781623C>T c.1385G>A p.R462K RefSeq GRCh38/hg38
XM_005250045 chr7:g.140781623C>T c.1385G>A p.R462K RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140781623C>T c.1385G>A p.R462K RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140781623C>T c.1385G>A p.R462K RefSeq GRCh38/hg38

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References