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Gene BRAF
Variant T599_V600insEAT
Impact List insertion
Protein Effect gain of function - predicted
Gene Variant Descriptions BRAF T599_V600insEAT results in the insertion of three amino acids in the protein kinase domain of the Braf protein between amino acids 599 and 600 (UniProt.org). T599_V600insEAT has not been characterized however, other insertions between T599 and V600 are activating (PMID: 16501605, PMID: 17297294, PMID: 21190184), and therefore, T599_V600insEAT is predicted to lead to a gain of Braf protein function.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF act mut BRAF T599_V600insEAT

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Transcript NM_004333.6
gDNA chr7:g.140753340_140753341insTGCCTCTGT
cDNA c.1798_1799insAGGCAACAG
Protein p.T599_V600insEAT
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005250045 chr7:g.140753340_140753341insTGCCTCTGT c.1798_1799insAGGCAACAG p.T599_V600insEAT RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140753340_140753341insTGCCTCTGT c.1798_1799insAGGCAACAG p.T599_V600insEAT RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140753340_140753341insTGCCTCTGT c.1798_1799insAGGCAACAG p.T599_V600insEAT RefSeq GRCh38/hg38
NM_004333 chr7:g.140753340_140753341insTGCCTCTGT c.1798_1799insAGGCAACAG p.T599_V600insEAT RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140753340_140753341insTGCCTCTGT c.1798_1799insAGGCAACAG p.T599_V600insEAT RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140753340_140753341insTGCCTCTGT c.1798_1799insAGGCAACAG p.T599_V600insEAT RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140753340_140753341insTGCCTCTGT c.1798_1799insAGGCAACAG p.T599_V600insEAT RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140753340_140753341insTGCCTCTGT c.1798_1799insAGGCAACAG p.T599_V600insEAT RefSeq GRCh38/hg38

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries