ALK I1171T
Gene Variant Detail

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Gene ALK
Variant I1171T
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions ALK I1171T lies within the protein kinase domain of the Alk protein (UniProt.org). I1171T confers a gain of function on the Alk protein as indicated by ligand-independent autophosphorylation, activation of Erk1/2, and cell transformation (PMID: 29907598), and has been demonstrated to confer drug resistance in the context of ALK fusions in culture (PMID: 27009859).
Associated Drug Resistance Y
Category Variants Paths

ALK mutant ALK act mut ALK I1171T

ALK mutant ALK I1171X ALK I1171T

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Transcript NM_004304.5
gDNA chr2:g.29222347A>G
cDNA c.3512T>C
Protein p.I1171T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304 chr2:g.29222347A>G c.3512T>C p.I1171T RefSeq GRCh38/hg38
NM_004304.4 chr2:g.29222347A>G c.3512T>C p.I1171T RefSeq GRCh38/hg38
NM_004304.5 chr2:g.29222347A>G c.3512T>C p.I1171T RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
ALK I1171T gain of function
EML4 - ALK ALK I1171T Ceritinib Lorlatinib TAE684
ALK rearrange ALK I1171T
EML4 - ALK ALK C1156Y ALK I1171T
EML4 - ALK ALK I1171T ALK G1269A
ALK I1171T ALK pos
EML4 - ALK ALK E1129V ALK I1171T ALK F1174C ALK F1174L ALK F1174V ALK G1269A
EML4 - ALK ALK I1171T ALK F1174V
EML4 - ALK ALK I1171T ALK F1174L ALK L1196M ALK D1203N ALK E1210K ALK G1269A
ALK I1171T ALK R1192P ALK L1196M ALK F1245V
EML4 - ALK ALK C1156Y ALK I1171T ALK L1198F