BRAF F516G
Gene Variant Detail

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Gene BRAF
Variant F516G
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF F516G lies within the protein kinase domain of the Braf protein (UniProt.org). F516G has been identified in the scientific literature (PMID: 24112705), but has not been biochemically characterized and therefore, its effect on Braf protein function is unknown (PubMed, Sep 2025).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF F516G

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Transcript NM_004333.6
gDNA chr7:g.140777059_140777060delTTinsGG
cDNA c.1546_1547delTTinsGG
Protein p.F516G
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001378474.1 chr7:g.140777059_140777060delTTinsGG c.1546_1547delTTinsGG p.F516G RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140777059_140777060delTTinsGG c.1546_1547delTTinsGG p.F516G RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140777059_140777060delTTinsGG c.1546_1547delTTinsGG p.F516G RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140777059_140777060delTTinsGG c.1546_1547delTTinsGG p.F516G RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140777059_140777060delTTinsGG c.1546_1547delTTinsGG p.F516G RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References