RET D631_L633delinsV
Gene Variant Detail

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Gene RET
Variant D631_L633delinsV
Impact List indel
Protein Effect unknown
Gene Variant Descriptions RET D631_L633delinsV results in a deletion of three amino acids in the extracellular domain of the Ret protein from amino acids 631 to 633, combined with the insertion of one valine (V) at the same site (UniProt.org). D631_L633delinsV has been identified in the sequencing studies (PMID: 32846061), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Nov 2025).
Associated Drug Resistance
Category Variants Paths

RET mutant RET D631_L633delinsV

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Transcript NM_020975.6
gDNA chr10:g.43114492_43114497delACGAGC
cDNA c.1892_1897delACGAGC
Protein p.D631_L633delinsV
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020975.6 chr10:g.43114492_43114497delACGAGC c.1892_1897delACGAGC p.D631_L633delinsV RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43114492_43114497delACGAGC c.1892_1897delACGAGC p.D631_L633delinsV RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43114492_43114497delACGAGC c.1892_1897delACGAGC p.D631_L633delinsV RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43114492_43114497delACGAGC c.1892_1897delACGAGC p.D631_L633delinsV RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43114492_43114497delACGAGC c.1892_1897delACGAGC p.D631_L633delinsV RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43114492_43114497delACGAGC c.1892_1897delACGAGC p.D631_L633delinsV RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Protein Effect Treatment Approaches
RET D631_L633delinsV unknown