BRAF K483T
Gene Variant Detail

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Gene BRAF
Variant K483T
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF K483T lies within the protein kinase domain of the Braf protein (UniProt.org). K483T has been identified in the scientific literature (PMID: 32234759), but has not been biochemically characterized and therefore, its effect on Braf protein function is unknown (PubMed, Apr 2026).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF K483T

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Transcript NM_004333.6
gDNA chr7:g.140778060T>G
cDNA c.1448A>C
Protein p.K483T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001378474.1 chr7:g.140778060T>G c.1448A>C p.K483T RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140778060T>G c.1448A>C p.K483T RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140778060T>G c.1448A>C p.K483T RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140778060T>G c.1448A>C p.K483T RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140778060T>G c.1448A>C p.K483T RefSeq GRCh38/hg38

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References