ALK L1240V
Gene Variant Detail

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Gene ALK
Variant L1240V
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions ALK L1240V lies within the protein kinase domain of the Alk protein (UniProt.org). L1240V results in transforming activity in cell culture (PMID: 25517749), and therefore, is predicted to lead to a gain of Alk protein function.
Associated Drug Resistance
Category Variants Paths

ALK mutant ALK act mut ALK L1240V

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Transcript NM_004304.5
gDNA chr2:g.29214009A>C
cDNA c.3718T>G
Protein p.L1240V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304.5 chr2:g.29214009A>C c.3718T>G p.L1240V RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References