HRAS A146P
Gene Variant Detail

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Gene HRAS
Variant A146P
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions HRAS A146P lies within the SAK motif of the Hras protein (PMID: 24224811). A146P has not been characterized, but can be predicted to lead to a gain of Hras protein function and activation of downstream signaling based on the effects of HRAS A146T (PMID: 24224811, PMID: 21850009).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS act mut HRAS A146P

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Transcript NM_005343.4
gDNA chr11:g.533467C>G
cDNA c.436G>C
Protein p.A146P
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001130442.3 chr11:g.533467C>G c.436G>C p.A146P RefSeq GRCh38/hg38
NM_176795.5 chr11:g.533467C>G c.436G>C p.A146P RefSeq GRCh38/hg38
NM_005343.4 chr11:g.533467C>G c.436G>C p.A146P RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
HRAS A146P head and neck squamous cell carcinoma sensitive Darlifarnib Preclinical - Pdx Actionable In a preclinical study, Darlifarnib (KO-2806) inhibited tumor growth in a patient-derived xenograft (PDX) model of head and neck squamous cell carcinoma harboring HRAS A146P (PMID: 41661652). 41661652