Therapy Detail
Contact
Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
| Therapy Name | Darlifarnib |
| Synonyms | |
| Therapy Description |
Darlifarnib (KO-2806) is a farnesyltransferase inhibitor, which may inhibit the Mtor pathway, leading to cell cycle arrest and inhibition of cell growth (Mol Cancer Ther (2023) 22 (12_Supplement): B024). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Darlifarnib | KO 2806|KO2806|KO-2806 | Farnesyltransferase Inhibitor 4 | Darlifarnib (KO-2806) is a farnesyltransferase inhibitor, which may inhibit the Mtor pathway, leading to cell cycle arrest and inhibition of cell growth (Mol Cancer Ther (2023) 22 (12_Supplement): B024). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| HRAS A146P | head and neck squamous cell carcinoma | sensitive | Darlifarnib | Preclinical - Pdx | Actionable | In a preclinical study, Darlifarnib (KO-2806) inhibited tumor growth in a patient-derived xenograft (PDX) model of head and neck squamous cell carcinoma harboring HRAS A146P (PMID: 41661652). | 41661652 |
| HRAS G13R | head and neck squamous cell carcinoma | sensitive | Darlifarnib | Preclinical - Pdx | Actionable | In a preclinical study, Darlifarnib (KO-2806) inhibited tumor growth more efficiently than Zarnestra (tipifarnib) and induced tumor regression in a patient-derived xenograft (PDX) model of head and neck squamous cell carcinoma harboring HRAS G13R (PMID: 41661652). | 41661652 |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06026410 | Phase I | Cabozantinib Cabozantinib + Darlifarnib Adagrasib + Darlifarnib Darlifarnib | KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors (FIT-001) | Recruiting | USA | ITA | FRA | ESP | DEU | 0 |
CKB BOOST