FBXW7 R689W - Gene Variant Detail

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Gene FBXW7
Variant R689W
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions FBXW7 R689W does not lie within any known functional domains of the Fbxw7 protein (UniProt.org). R689W results in increased levels of phosphorylated Rictor, Akt, Gsk, and p70s6 (PMID: 29963728), and decreased interaction with the T244 degron of Myc in the context of an F-box domain deletion in culture (PMID: 35089787), and therefore, is predicted to lead to a loss of Fbxw7 protein function.
Associated Drug Resistance
Category Variants Paths

FBXW7 mutant FBXW7 inact mut FBXW7 R689W

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Transcript NM_033632.3
gDNA chr4:g.152322940G>A
cDNA c.2065C>T
Protein p.R689W
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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