NTRK2 over exp
Gene Variant Detail

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Gene NTRK2
Variant over exp
Impact List none
Protein Effect no effect
Gene Variant Descriptions NTRK2 over exp indicates an over expression of the Ntrk2 protein. However, the mechanism causing the over expression is unspecified.
Associated Drug Resistance
Category Variants Paths

NTRK2 over exp

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No Variant Reference Transcript is Available.
No transcript is Available.

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
NTRK2 over exp neuroblastoma sensitive AZ64 + Irinotecan + Temozolomide Preclinical - Cell line xenograft Actionable In a preclinical study, AZ64 in combination with Camptosar (irinotecan) and Temodar (temozolomide) improved event-free survival and reduced tumor growth in neuroblastoma cell line xenograft models over expressing Ntrk2 (TrkB), with increased efficacy over chemotherapy alone (PMID: 22623209). 22623209
NTRK2 over exp neuroblastoma sensitive AZ64 Preclinical - Cell line xenograft Actionable In a preclinical study, AZ64 inhibited tumor growth in neuroblastoma cell line xenograft models over expressing Ntrk2 (TrkB) (PMID: 22623209). 22623209