ERBB3 K742E
Gene Variant Detail

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Gene ERBB3
Variant K742E
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ERBB3 (HER3) K742E lies within the protein kinase domain of the Erbb3 (Her3) protein (UniProt.org). K742E has been identified in the scientific literature (PMID: 29963236), but has not been biochemically characterized and therefore, its effect on Erbb3 (Her3) protein function is unknown (PubMed, May 2026).
Associated Drug Resistance
Category Variants Paths

ERBB3 mutant ERBB3 K742E

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Transcript NM_001982.4
gDNA chr12:g.56096796A>G
cDNA c.2224A>G
Protein p.K742E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001982 chr12:g.56096796A>G c.2224A>G p.K742E RefSeq GRCh38/hg38
NM_001982.3 chr12:g.56096796A>G c.2224A>G p.K742E RefSeq GRCh38/hg38
NM_001982.4 chr12:g.56096796A>G c.2224A>G p.K742E RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ERBB3 mutant invasive bladder transitional cell carcinoma predicted - sensitive Cisplatin + Gemcitabine + Sorafenib Phase II Actionable In a Phase II trial, ERBB3 mutations were only detected in patients with muscle-invasive urothelial bladder cancer that responded to Nexavar (sorafenib), Platinol (cisplatin) and Gemzar (gemcitabine) combination therapy (J Clin Oncol 35, 2017 (suppl 6S; abstract 345)). detail...
ERBB3 mutant Advanced Solid Tumor no benefit Neratinib Phase II Actionable In a Phase II trial (SUMMIT), Nerlynx (neratinib) treatment resulted in no objective response, a clinical benefit rate of 12.5% (2/16), and a median progression-free survival of 1.7 months in patients with advanced solid tumors harboring ERBB3 (HER3) mutations (PMID: 29420467; NCT01953926). 29420467