ERBB4 D931Y
Gene Variant Detail

Request Content

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene ERBB4
Variant D931Y
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions ERBB4 D931Y lies within the protein kinase domain of the Erbb4 protein (UniProt.org). D931Y does not lead to cell transformation in culture (PMID: 34741886) but confers a gain of function to the Erbb4 protein as demonstrated by increased receptor transactivation, heterdimerization with Erbb2 (Her2), and increased Erbb4 phosphorylation (PMID: 26050618).
Associated Drug Resistance
Category Variants Paths

ERBB4 mutant ERBB4 act mut ERBB4 D931Y

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_005235.3
gDNA chr2:g.211424230C>A
cDNA c.2791G>T
Protein p.D931Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_005235 chr2:g.211424230C>A c.2791G>T p.D931Y RefSeq GRCh38/hg38
NM_005235.2 chr2:g.211424230C>A c.2791G>T p.D931Y RefSeq GRCh38/hg38
NM_005235.3 chr2:g.211424230C>A c.2791G>T p.D931Y RefSeq GRCh38/hg38
NM_001042599.1 chr2:g.211424230C>A c.2791G>T p.D931Y RefSeq GRCh38/hg38
NM_001042599.1 chr2:g.211424230C>A c.2791G>T p.D931Y RefSeq GRCh38/hg38
NM_001042599 chr2:g.211424230C>A c.2791G>T p.D931Y RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
ERBB4 D931Y gain of function Lapatinib