PIK3CA E542K
Gene Variant Detail

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Gene PIK3CA
Variant E542K
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions PIK3CA E542K is a hotspot mutation that lies within the PIK helical domain of the Pik3ca protein (UniProt.org). E542K results in increased PI3K activity and phosphorylation of Akt (PMID: 15647370), increased cell invasion (PMID: 26627007), and is transforming in cultured cells (PMID: 15647370, PMID: 26627007, PMID: 29533785, PMID: 17376864).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA act mut PIK3CA E542K

PIK3CA mutant PIK3CA exon10 PIK3CA E542X PIK3CA E542K

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Transcript NM_006218.4
gDNA chr3:g.179218294G>A
cDNA c.1624G>A
Protein p.E542K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011512894 chr3:g.179218294G>A c.1624G>A p.E542K RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179218294G>A c.1624G>A p.E542K RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179218294G>A c.1624G>A p.E542K RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179218294G>A c.1624G>A p.E542K RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179218294G>A c.1624G>A p.E542K RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179218294G>A c.1624G>A p.E542K RefSeq GRCh38/hg38
NM_006218 chr3:g.179218294G>A c.1624G>A p.E542K RefSeq GRCh38/hg38
XM_006713658 chr3:g.179218294G>A c.1624G>A p.E542K RefSeq GRCh38/hg38

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT07522697 Phase II Inavolisib Inavolisib for PIK3CA Mutated Advanced Endometrial Cancer: MITO END-4 (MITO END-4) Not yet recruiting ITA 0
NCT04586335 Phase I CYH33 + Olaparib Study of CYH33 in Combination With Olaparib an Oral PARP Inhibitor in Patients With Advanced Solid Tumors. Terminated USA | AUS 1
NCT05455619 Phase Ib/II Capivasertib + Fulvestrant + SDX-7320 Alpelisib + Fulvestrant + SDX-7320 Evexomostat Plus PI3K or AKT Inhibitor and Fulvestrant in Patients With a PI3K Alteration and HR+/ Her2- Breast Cancer (Amelia-1) Recruiting USA 0