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Gene CDK12
Variant G909E
Impact List missense
Protein Effect unknown
Gene Variant Descriptions CDK12 G909E lies within the protein kinase domain of the Cdk12 protein (PMID: 22512864). G909E results in increased androgen receptor activation compared to wild-type Cdk12 and is associated with resistance to anti-androgen therapy in cultured cells (PMID: 36129942), but has not been fully biochemically characterized and therefore, its effect on Cdk12 protein function is unknown.
Associated Drug Resistance Y
Category Variants Paths

CDK12 mutant CDK12 G909E

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Transcript NM_016507.4
gDNA chr17:g.39511588G>A
cDNA c.2726G>A
Protein p.G909E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011524898.3 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_047436260.1 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_011524906.2 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_011524906.3 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_047436277.1 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_011524895 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_047436259.1 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_011524893.2 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_011524900.2 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_011524892.2 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_005257458.4 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_011524900 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
NM_015083.2 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_047436268.1 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_017024750.1 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_047436275.1 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_011524895.3 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_047436256.1 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_011524894.2 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_047436266.1 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_047436279.1 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_011524899 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_017024746 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_047436274.1 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_011524903.2 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_047436272.1 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_011524896.2 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_011524901 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_011524898 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_047436287.1 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_047436289.1 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_017024744 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_017024747 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_017024752 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_047436265.1 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_011524899.2 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
NM_016507.3 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_011524906 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_005257458 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_047436288.1 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_011524896 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_011524905.2 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_011524905 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_047436269.1 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_011524907.3 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_047436258.1 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_011524907 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_011524903 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
NM_015083.4 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_047436293.1 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_017024750 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_011524897 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_011524902 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_024450801.1 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_047436273.1 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_011524902.2 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_017024751.1 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_047436257.1 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_011524894 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_017024747.1 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_011524898.2 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_011524897.3 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_011524901.2 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_017024749.1 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_047436270.1 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_017024749 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_011524892 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_017024748 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_011524897.2 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_047436276.1 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_011524907.2 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_011524893 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_017024745 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
NM_015083 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_011524894.3 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_047436261.1 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_047436278.1 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_017024751 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_047436255.1 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_017024748.1 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
NM_016507 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_011524895.2 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_011524893.3 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_047436267.1 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
XM_017024752.1 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38
NM_016507.4 chr17:g.39511588G>A c.2726G>A p.G909E RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CDK12 G909E prostate cancer predicted - resistant Enzalutamide Preclinical - Cell culture Actionable In a preclinical study, expression of CDK12 G909E in prostate cancer cells was associated with increased growth in the presence of Xtandi (enzalutamide) in culture (PMID: 36129942). 36129942