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Profile Name | CDK12 G909E |
Gene Variant Detail | |
Relevant Treatment Approaches |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
CDK12 G909E | prostate cancer | predicted - resistant | Enzalutamide | Preclinical - Cell culture | Actionable | In a preclinical study, expression of CDK12 G909E in prostate cancer cells was associated with increased growth in the presence of Xtandi (enzalutamide) in culture (PMID: 36129942). | 36129942 |